Our culture says: "Our greatest human need is to know we're worthy."
God says: Without God we're worthless sinners (Romans 3:10-12,23). Our greatest need is to know that God is worthy (Psalm 111:10).
Our culture says: "Each person must decide what is right or wrong for themselves."
God says: The difference between right and wrong is obvious (Galatians 5:19-20). It's written on each man's heart (Romans 2:12-16), and anyone who says otherwise is self-deceived (1 John 1:7-9).
Our culture says: "If you live a good life, you'll go to heaven."
God says: Sin leads to eternal death (Romans 6:23), no amount of good works will save us (Ephesians 2:8-9), and Jesus is the only way to be saved (John 14:6).
Our culture says: "You can't judge me. In fact, the Bible says not to judge me."
God says: Judge beliefs, (1) sin, and sinners. (2) Just make sure you judge yourself first.* (3).
It's important that we understand these truths, transmit them clearly to others, and live them!
* judging yourself first doesn't mean you have to be perfect in order to judge another person. It means that you shouldn't judge someone for the same thing you are doing.